Skin boosters explained: biorevitalisation, Profhilo, polynucleotides and collagen stimulators
Prices as of 24.10.2026
Skin boosters compared: the four groups side by side
Typical ranges, not a promise.
| Biorevitalisation | Bioremodelling (Profhilo) | Polynucleotides | Collagen stimulators | |
|---|---|---|---|---|
| Ingredient | non-cross-linked hyaluronic acid | concentrated hyaluronic acid | salmon or trout DNA fragments | PLLA, calcium hydroxylapatite, PCL |
| What it does | hydrates | hydrates and supports elasticity | supports skin repair | builds own collagen |
| Who it suits | dry, dull skin, fine lines | loss of elasticity, neck, hands | thin skin, eye area, scars | thinning and laxity |
| Course | 2–3 sessions, 2–4 weeks apart | 2 sessions, about 4 weeks apart | 2–4 sessions, 2–4 weeks apart | PLLA: 2–3 sessions, 4–10 weeks apart |
| Results show | within days to a week | in 5–10 days, full 4–6 weeks after the 2nd | within days | gradually over 2–6 months |
| Typically lasts | 3–6 months | 6–12 months | 3–6 months | 12–18 months |
| At Melior, e.g. | RRS Hyalift 75, EJAL 40, Jalupro Super Hydro | Profhilo, Profhilo Structura, Karisma | HP Cell Vitaran I and II, HH PDRN | HH PLLA, Lanluma, Radiesse, Ellansé |
Which skin booster for which concern?
Start from the concern, not the product.
Dry, dull skin, fine lines
Biorevitalisation first; bioremodelling if elasticity is also lower.
Polynucleotides under the eyes
HP Cell Vitaran I for thin skin. Dark circles and puffiness depend on their cause.
Loss of firmness, softer jawline
Milder cases: Profhilo or Profhilo Structura; visible laxity: collagen stimulators.
Neck, décolletage, hands
Dryness: biorevitalisation or Profhilo; laxity: PLLA or calcium hydroxylapatite.
Lost volume or a deep line
Not a skin booster task: botulinum toxin vs fillers.
When do skin boosters show results?
Tap a point on the scale.
First week
Biorevitalisation: hydration within days to a week. Polynucleotides: fresher skin within days.
Days 5–10
Profhilo: first changes. The second session follows about 4 weeks later, with the full effect 4–6 weeks after it.
2–3 weeks
Polynucleotides: a more visible change.
6–8 weeks
PLLA: first visible changes as the skin builds its own collagen. PLLA gives no immediate volume.
2–6 months
Collagen stimulators build up gradually. Radiesse gives light support straight away, with the final result over 2–3 months; PLLA shows its biggest change at 3–6 months.
Up to 12–18 months
How long collagen stimulators usually last; Lanluma up to 2 years. Biorevitalisation and polynucleotides last 3–6 months, Profhilo 6–12. The first time, the effect may be shorter.
How many sessions are needed?
Consultation
The specialist assesses the skin, asks about health, medication and allergies (fish, for polynucleotides) and chooses the product.
Treatment
20–60 minutes of light pinching or pressure; numbing cream if needed.
Course
Usually 2–4 sessions: biorevitalisation 2–3, Profhilo 2, polynucleotides 2–4, PLLA 2–3.
Maintenance
Biorevitalisation and polynucleotides every 3–6 months, Profhilo about yearly, collagen stimulators once the effect fades. Courses often start in autumn or winter.
Side effects and risks
Downsides: a course, a temporary effect, slow collagen results.
Common
- redness, swelling, tenderness – 1–3 days
- mosquito-bite bumps after biorevitalisation
- sometimes a bruise; more swelling around the eyes
Less common
- nodules, mainly after PLLA
- inflammation, cold sore, allergy
Let the clinic know
Very rare but urgent
- skin turns pale or bluish at the injection site
- pain gets worse
- vision changes
Contact the clinic at once, or 112
In more detail
Skin boosters in plain words
Injections that improve the skin itself, not the shape of the face. Hyaluronic acid holds water, collagen gives density, elastin gives bounce; with age, sun, smoking and stress the skin makes less of them.
Rule of thumb: hydration concerns point to hyaluronic acid; density and support concerns point to collagen-stimulating products.
Profhilo vs skin booster
Profhilo is a skin booster, but works differently from classic biorevitalisation, which uses many shallow micro-injections and lasts about 3–6 months. Profhilo is more concentrated, injected into five points per side; it spreads slowly, also supports elasticity and typically lasts 6–12 months after 2 sessions.
Products and compositions: biorevitalisation treatments and Profhilo bioremodelling.
Polynucleotides: how well studied?
Purified DNA fragments from salmon or trout. They add no volume; they support skin repair, collagen and elastin production, and calm inflammation.
A systematic review of 9 studies with 219 patients found them well tolerated, with mostly mild side effects, but the studies were small and the evidence is still limited. At Melior: HP Cell Vitaran II, and HP Cell Vitaran I for the eye area.
Radiesse vs PLLA
Both stimulate collagen around microparticles that break down gradually. Radiesse (calcium hydroxylapatite) gives some immediate support; PLLA gives no immediate volume. Ellansé (PCL) combines a filler effect with collagen stimulation.
After PLLA, massage by the 5–5–5 rule (5 days, 5 times a day, 5 minutes) is often advised; after Radiesse the area is not massaged. Neither can be dissolved with an enzyme, and neither replaces a surgical lift.
Who should not have skin boosters?
Usually not during pregnancy or breastfeeding; with inflammation, infection or a cold sore in the area, or fever; with an allergy to an ingredient (fish, for polynucleotides); with untreated autoimmune disease or immune-suppressing medication, a bleeding disorder, poorly controlled diabetes or a recent invasive procedure in the area; or, for collagen stimulators, a tendency to keloids.
Medicines prescribed by your own doctor are not stopped without their advice. The specialist decides.
Aftercare: what to avoid
First 2–4 hours: leave the injection points alone. 24 hours: no make-up (at least 12 hours after Profhilo), alcohol or workouts. 48 hours: no sauna, hot bath, intense exercise or sunbed. Up to 2 weeks: no laser or chemical peels; SPF 50 and at least a week without tanning.
Frequently asked questions
Do skin boosters hurt?
Most people feel a light pinching or pressure. The needles are very fine, a numbing cream can be used and some products have anaesthetic added. The eye area tends to be more sensitive than the cheeks.
How much do skin boosters cost in Tallinn?
At Melior Clinics, prices start from €175 for biorevitalisation, €225 for bioremodelling, €200 for polynucleotides and €350 for collagen stimulators per treatment (price list of 24.10.2026). A course usually means 2–4 treatments.
How long does Profhilo last?
Typically 6–12 months after a course of two sessions; most studies followed results for about six months.
Profhilo vs polynucleotides: what’s the difference?
Profhilo mainly hydrates and supports elasticity on the face, neck and hands. Polynucleotides focus on skin repair and suit thin, sensitive skin, including under the eyes. The two are sometimes combined; the specialist decides after assessing the skin.
Will my skin look worse if I stop?
No. If treatments are not repeated, the skin gradually returns to its earlier state and keeps ageing at its usual pace. The skin does not become dependent on injections.
Can skin boosters be combined with botulinum toxin?
Yes, they are often combined. Botulinum toxin relaxes the expression muscles, while skin boosters work on the skin itself. The specialist decides the order and the gap between treatments.
Biorevitalisation vs mesotherapy: which one?
Both use micro-injections. Mesotherapy cocktails contain more vitamins, amino acids and minerals and usually less hyaluronic acid. Biorevitalisation focuses on hydration with hyaluronic acid, so it is more often chosen for dry, dehydrated skin. The two can be combined.
Skin boosters in Tallinn
Read next
- Rho N-K, Kim H-S, Kim S-Y, Lee W. Injectable "Skin Boosters" in Aging Skin Rejuvenation: A Current Overview. Arch Plast Surg. 2024;51(6):528–541
- Tintor G, et al. Hybrid Cooperative Complexes of Low- and High-Molecular-Weight Hyaluronic Acid in Aesthetic Medicine. Pharmaceuticals (Basel). 2025;19(1):73
- Lampridou S, Bassett S, Cavallini M, Christopoulos G. The Effectiveness of Polynucleotides in Esthetic Medicine: A Systematic Review. J Cosmet Dermatol. 2025;24(2):e16721
- American Academy of Dermatology. Fillers: FAQs
This article is general information and does not replace a consultation. Whether a treatment suits you is decided by a specialist at the consultation. Melior Clinics (Star Company OÜ), Liivalaia 53, Tallinn · Estonian Health Board licence L04198.
